THE STUDY OF ESTABLISHMENT OF AN IN VIVO TUMOR MODEL BY THREE-DIMENSIONAL CELLS CULTURE SYSTEMS METHODS AND EVALUATION OF ANTITUMOR EFFECT OF BIOTIN-CONJUGATED PULLULAN ACETATE NANOPARTICLES

In this study, three-dimensional (3D) hydrogels were used for human hepatocellular carcinoma (HepG2) cells culture systems in vitro and establishment of an in vivo xenografted tumor model.Based on our previous work on the biotin-conjugated pullulan Vinyl acetate nanoparticles (Bio-PA NPs) as anticancer drug carriers, we further studied the anti-tum

Tuberculosis (TB) is still a major public health problem in the world, with many factors contributing to this burden, including poor living conditions, overcrowding, poverty, malnutrition, illiteracy, and rapid spread of human immunodeficiency virus infection.Cutaneous tuberculosis is a less common form of extrapulmonary tuberculosis, and in this p

Before discussing the issues related to influenza pandemics, it is necessity to understand the mechanisms that underlie the variability, of the virus.The influenza virus, like most RNA viruses, is genetically highly variable and this variability gives rise to a constant changing of the antigenicity of the virus.This, in itself, is not peculiar to i

[Background] Functional disorders (FD) are present across the age span and are commonly encountered in somatic health care.Psychological therapies have proven effective, but mostly the effects are slight to moderate.The advent of third wave cognitive behavioural therapies launched an opportunity to potentially improve treatments for FD.[Method] A n